Journal:

Article Title: Extended Analysis of the In Vitro Tropism of Porcine Endogenous Retrovirus

doi:

Figure Lengend Snippet: Relative susceptibility of nonhuman cell lines to infection by PERV-NIH-2°-derived PERV pseudotypes

Article Snippet: 293 human embryonic kidney (ATCC CRL-1573), MMK Mus musculus molossinus kidney (ATCC CRL-6439; no longer available), and SC-1 mouse embryo epithelial (ATCC CRL-6450) cells, MDTF Mus dunni tail fibroblasts (kindly provided by Olivier Danos), NRK normal rat kidney cells (ATCC CRL-6509), Rat-2 rat embryo fibroblasts (ATCC CRL-1764), SIRC rabbit corneal fibroblasts (ATCC CCL-60), D17 canine oseosarcoma (ATCC CRL-6248), MDBK bovine kidney epithelium (ATCC CCL-22), FRhK4 rhesus monkey kidney (ATCC CRL-1688), Mv1Lu mink lung epithelial (ATCC CCL-64), and MiCL.1 (S+L−) mink lung (ATCC CCL-64.1) cells, Fc3TG feline tongue fibroblasts (ATCC CCL 176), and AK-D feline lung epithelial (ATCC CCL-150), CRFK feline kidney epithelial (ATCC CCL-94), CaKi-1 clear cell kidney carcinoma (ATCC HTB-46), HeLa cervical adenocarcinoma (ATCC CCL-2), HOS human osteosarcoma (ATCC CRL-1543), and CaCO-2 colorectal adenocarcinoma (ATCC HTB-37) cells were maintained in Dulbecco's modified Eagle's medium supplemented with 10% fetal bovine serum (FBS), 2 mM glutamine, 1 mM sodium pyruvate, 100 U of penicillin per ml, and 100 μg of streptomycin per ml.

Techniques: Infection

Journal: Neurobiology of disease

Article Title: Finding intestinal fortitude: Integrating the microbiome into a holistic view of depression mechanisms, treatment, and resilience

doi: 10.1016/j.nbd.2019.104578

Figure Lengend Snippet: Illustration of reviewed bidirectional communication between the central nervous system, endocrine system, and immune system and the microbiome, which contribute to depression.

Article Snippet: 23 ( Hoban, Stilling, et al., 2016 ) Afferent (microbiota to system) Mouse GF mice None None NA IS: None Reported ES: None Reported CNS: GF mice have elevated expression of genes related to myelination and myelin plasticity, as well as hypermyelination of axons, all in the PFC 24 ( Bravo et al., 2011 ) Afferent (microbiota to system) Mouse none L. rhamnosus JB-1 Forced swim test Probiotic treatment decreased depression-like behaviors induced by the forced swim test IS: None Reported ES: None Reported CNS: Probiotic treatment ↓ Gabra2 mRNA in the PFC; ↓ Gabbr1 and ↓ Gabra2 mRNA in the amygdala; ↓ Gabbr1 mRNA in CA1, CA3, and the dentate gyrus of the hippocampus; ↑ Gabra2 mRNA in the hippocampal dentate gyrus; ↓ Gabbr1b in locus coeruleus; ↑ Gabbr1b in cingulate area 1; and ↑ Gabbr1b in prelimbic cortex 25 ( Neufeld, et al., 2011 ) Afferent (microbiota to system) Mouse None None Elevated plus-maze GF mice exhibited decreased anxiety-like behavior as compared to SPF mice IS: None Reported ES: None Reported CNS: GF mice had ↓ Grin2b mRNA in the central amygdala; and ↑ Bdnf mRNA and ↓ Htr1a mRNA in the hippocampal dentate gyrus 26 ( Bercik, Denou, et al., 2011 ) Afferent (microbiota to system) Mouse 7-day antibiotic treatment FMT Antibiotics, FMT Light/dark preference test, Step-down test Antibiotic treatment decreased anxiety-like behaviors induced by antibiotics IS: None Reported ES: None Reported CNS: Antibiotic treatment ↓ BDNF levels in the amygdala, which was reversed by FMT 27 ( Desbonnet et al., 2010 ) Afferent (microbiota to system) Rat Maternal separation model B. infantis 35624 Forced swim test Probiotic treatment reversed depression-like symptoms induced by maternal separation IS: None Reported ES: None Reported CNS: Probiotic treatment attenuated a maternal separation-induced ↓ in norepinephrine levels in the brainstem, but did not affect circulating tryptophan, kynurenine, or kynurenic acid concentrations 28 ( Bercik, Park, et al., 2011 ) Afferent (microbiota to system) Mouse Dextran sodium sulfate (DSS)-induced chemical colitis B. longum NCC3001, subdiaphragmatic vagotomy Step-down test Vagotomy and probiotic treatment either prevented or normalized anxiety-like behaviors induced by DSS IS: None Reported ES: None Reported CNS: Probiotic treatment did not affect Bdnf mRNA expression in cultured human SH-SY5Y neuroblastoma cells treated with serum of probiotic-treated mice 29 ( Marin et al., 2017 ) Afferent (microbiota to system) Mouse Chronic mild stress L. reuteri ATCC 23272 Forced swim test Probiotic treatment reversed depression-like behavior induced by stressor IS: None Reported ES: None Reported CNS: Stress ↓ fecal Lactobacillus spp., ↑ circulating kynurenine, and ↑ fecal Ido1 mRNA.

Techniques:

Journal: Neurobiology of disease

Article Title: Finding intestinal fortitude: Integrating the microbiome into a holistic view of depression mechanisms, treatment, and resilience

doi: 10.1016/j.nbd.2019.104578

Figure Lengend Snippet: Afferent and efferent signaling along the microbiome-gut-brain axis, preclinical studies

Article Snippet: 23 ( Hoban, Stilling, et al., 2016 ) Afferent (microbiota to system) Mouse GF mice None None NA IS: None Reported ES: None Reported CNS: GF mice have elevated expression of genes related to myelination and myelin plasticity, as well as hypermyelination of axons, all in the PFC 24 ( Bravo et al., 2011 ) Afferent (microbiota to system) Mouse none L. rhamnosus JB-1 Forced swim test Probiotic treatment decreased depression-like behaviors induced by the forced swim test IS: None Reported ES: None Reported CNS: Probiotic treatment ↓ Gabra2 mRNA in the PFC; ↓ Gabbr1 and ↓ Gabra2 mRNA in the amygdala; ↓ Gabbr1 mRNA in CA1, CA3, and the dentate gyrus of the hippocampus; ↑ Gabra2 mRNA in the hippocampal dentate gyrus; ↓ Gabbr1b in locus coeruleus; ↑ Gabbr1b in cingulate area 1; and ↑ Gabbr1b in prelimbic cortex 25 ( Neufeld, et al., 2011 ) Afferent (microbiota to system) Mouse None None Elevated plus-maze GF mice exhibited decreased anxiety-like behavior as compared to SPF mice IS: None Reported ES: None Reported CNS: GF mice had ↓ Grin2b mRNA in the central amygdala; and ↑ Bdnf mRNA and ↓ Htr1a mRNA in the hippocampal dentate gyrus 26 ( Bercik, Denou, et al., 2011 ) Afferent (microbiota to system) Mouse 7-day antibiotic treatment FMT Antibiotics, FMT Light/dark preference test, Step-down test Antibiotic treatment decreased anxiety-like behaviors induced by antibiotics IS: None Reported ES: None Reported CNS: Antibiotic treatment ↓ BDNF levels in the amygdala, which was reversed by FMT 27 ( Desbonnet et al., 2010 ) Afferent (microbiota to system) Rat Maternal separation model B. infantis 35624 Forced swim test Probiotic treatment reversed depression-like symptoms induced by maternal separation IS: None Reported ES: None Reported CNS: Probiotic treatment attenuated a maternal separation-induced ↓ in norepinephrine levels in the brainstem, but did not affect circulating tryptophan, kynurenine, or kynurenic acid concentrations 28 ( Bercik, Park, et al., 2011 ) Afferent (microbiota to system) Mouse Dextran sodium sulfate (DSS)-induced chemical colitis B. longum NCC3001, subdiaphragmatic vagotomy Step-down test Vagotomy and probiotic treatment either prevented or normalized anxiety-like behaviors induced by DSS IS: None Reported ES: None Reported CNS: Probiotic treatment did not affect Bdnf mRNA expression in cultured human SH-SY5Y neuroblastoma cells treated with serum of probiotic-treated mice 29 ( Marin et al., 2017 ) Afferent (microbiota to system) Mouse Chronic mild stress L. reuteri ATCC 23272 Forced swim test Probiotic treatment reversed depression-like behavior induced by stressor IS: None Reported ES: None Reported CNS: Stress ↓ fecal Lactobacillus spp., ↑ circulating kynurenine, and ↑ fecal Ido1 mRNA.

Techniques: Inhibition, Activity Assay, Modification, Permeability, Translocation Assay, Expressing, Produced, Cell Culture, Mouse Assay

Journal: Neurobiology of disease

Article Title: Finding intestinal fortitude: Integrating the microbiome into a holistic view of depression mechanisms, treatment, and resilience

doi: 10.1016/j.nbd.2019.104578

Figure Lengend Snippet: Afferent and efferent signaling along the microbiome-gut-brain axis, clinical studies

Article Snippet: 23 ( Hoban, Stilling, et al., 2016 ) Afferent (microbiota to system) Mouse GF mice None None NA IS: None Reported ES: None Reported CNS: GF mice have elevated expression of genes related to myelination and myelin plasticity, as well as hypermyelination of axons, all in the PFC 24 ( Bravo et al., 2011 ) Afferent (microbiota to system) Mouse none L. rhamnosus JB-1 Forced swim test Probiotic treatment decreased depression-like behaviors induced by the forced swim test IS: None Reported ES: None Reported CNS: Probiotic treatment ↓ Gabra2 mRNA in the PFC; ↓ Gabbr1 and ↓ Gabra2 mRNA in the amygdala; ↓ Gabbr1 mRNA in CA1, CA3, and the dentate gyrus of the hippocampus; ↑ Gabra2 mRNA in the hippocampal dentate gyrus; ↓ Gabbr1b in locus coeruleus; ↑ Gabbr1b in cingulate area 1; and ↑ Gabbr1b in prelimbic cortex 25 ( Neufeld, et al., 2011 ) Afferent (microbiota to system) Mouse None None Elevated plus-maze GF mice exhibited decreased anxiety-like behavior as compared to SPF mice IS: None Reported ES: None Reported CNS: GF mice had ↓ Grin2b mRNA in the central amygdala; and ↑ Bdnf mRNA and ↓ Htr1a mRNA in the hippocampal dentate gyrus 26 ( Bercik, Denou, et al., 2011 ) Afferent (microbiota to system) Mouse 7-day antibiotic treatment FMT Antibiotics, FMT Light/dark preference test, Step-down test Antibiotic treatment decreased anxiety-like behaviors induced by antibiotics IS: None Reported ES: None Reported CNS: Antibiotic treatment ↓ BDNF levels in the amygdala, which was reversed by FMT 27 ( Desbonnet et al., 2010 ) Afferent (microbiota to system) Rat Maternal separation model B. infantis 35624 Forced swim test Probiotic treatment reversed depression-like symptoms induced by maternal separation IS: None Reported ES: None Reported CNS: Probiotic treatment attenuated a maternal separation-induced ↓ in norepinephrine levels in the brainstem, but did not affect circulating tryptophan, kynurenine, or kynurenic acid concentrations 28 ( Bercik, Park, et al., 2011 ) Afferent (microbiota to system) Mouse Dextran sodium sulfate (DSS)-induced chemical colitis B. longum NCC3001, subdiaphragmatic vagotomy Step-down test Vagotomy and probiotic treatment either prevented or normalized anxiety-like behaviors induced by DSS IS: None Reported ES: None Reported CNS: Probiotic treatment did not affect Bdnf mRNA expression in cultured human SH-SY5Y neuroblastoma cells treated with serum of probiotic-treated mice 29 ( Marin et al., 2017 ) Afferent (microbiota to system) Mouse Chronic mild stress L. reuteri ATCC 23272 Forced swim test Probiotic treatment reversed depression-like behavior induced by stressor IS: None Reported ES: None Reported CNS: Stress ↓ fecal Lactobacillus spp., ↑ circulating kynurenine, and ↑ fecal Ido1 mRNA.

Techniques: Translocation Assay, Concentration Assay, Diagnostic Assay, Binding Assay, Activity Assay, Injection, Permeability